![]() ![]() Patched 1, GPR161, SMO and other ciliary membrane proteins are all ferried out of cilia in a regulated manner by an evolutionarily conserved complex of eight Bardet-Biedl Syndrome (BBS) proteins, the BBSome ( Nachury, 2018 Wingfield et al., 2018). Regulated exit from cilia represents a general mechanism to redistribute signaling molecules on demand ( Nachury and Mick, 2019). ![]() Highlighting the functional importance of dynamic ciliary trafficking, the appropriate transduction of Hedgehog signal relies on the disappearance of the GPCR GPR161 and the Hedgehog receptor Patched 1 from cilia and the accumulation of the GPCR Smoothened (SMO) within cilia ( Bangs and Anderson, 2017). Cilia dynamically concentrate signaling receptors to sense and transduce signals as varied as light, odorant molecules, Hedgehog morphogens and ligands of G protein-coupled receptors (GPCRs) ( Anvarian et al., 2019 Bangs and Anderson, 2017 Nachury and Mick, 2019). ![]()
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